Key result
Treatment of hyperglycemia with insulin protected against inflammation and improved cardiac function in a rat model of LPS-induced systemic inflammation.
Why the study?
Does insulin therapy improve cardiac function and reduce inflammation in a rat model of LPS-induced systemic inflammation with hyperglycemia?
Population
Male Wistar rats in a lipopolysaccharide (LPS)-induced systemic inflammation model
Comparison
Insulin with glucose vs LPS without insulin (hyperglycemic rats)
Design
Preclinical
Authors
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Hypothesis-generating for insulin in septic cardiomyopathy; human trials needed before any clinical consideration.
Does insulin therapy improve cardiac function and reduce inflammation in a rat model of LPS-induced systemic inflammation with hyperglycemia?
Insulin therapy protects against inflammation and cardiac dysfunction in a preclinical model of LPS-induced systemic inflammation with hyperglycemia.
Hagiwara et al. (2009) studied LPS-induced systemic inflammation. Insulin with glucose vs. Hyperglycemia without insulin was evaluated on Cardiac function (+dP/dtmax and -dP/dtmin) and inflammatory mediators. Treatment of hyperglycemia with insulin protected against inflammation and improved cardiac function in a rat model of LPS-induced systemic inflammation.
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