March 1, 1995American Journal of Clinical Pathology
A Comparison of Lyophilized Artificially Depleted Plasmas and Lyophilized Plasmas From Patients Receiving Warfarin in Correcting for Coagulometer Effects on International Normalized Ratios
Why the study?
Do lyophilized artificially depleted plasmas perform similarly to plasmas from warfarin-treated patients in determining local system International Sensitivity Indices?
Population
95 local systems across 39 centers testing coagulometer effects on International Normalized Ratios (INR)
Comparison
Lyophilized artificially depleted plasmas vs Lyophilized plasmas from patients receiving…
Design
Other
Authors
Discussion
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Implication
Artificially depleted plasmas may substitute for patient plasmas in local ISI calibration; supports validation in larger, diverse cohorts before routine adoption.
Structured PICO
Do lyophilized artificially depleted plasmas perform similarly to plasmas from warfarin-treated patients in determining local system International Sensitivity Indices?
P
Population
95 local systems across 39 centers testing coagulometer effects on International Normalized Ratios (INR)
I
Intervention
Lyophilized artificially depleted plasmas
C
Comparator
Lyophilized plasmas from patients receiving warfarin
O
Outcome
Local system International Sensitivity Indices (ISI) determinationsurrogate
Artificially depleted plasmas can reliably substitute for plasmas from warfarin-treated patients for local ISI calibration, offering practical advantages in obtaining sufficient volumes and a wide range of INR values.
Cite This Study
Poller et al. (1995) studied this question.