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March 1, 1978British Journal of Haematology

Automated versus Manual Techniques for the Prothrombin Time Test: Results of Proficiency Assessment Studies

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Why the study?

Do automated techniques for the prothrombin time test reduce inter-laboratory error compared to manual techniques?

Population

Hospitals participating in prothrombin time proficiency assessment trials organized by the National…

Comparison

Automated procedures for the prothrombin time test vs Recommended manual technique for the prothrombin…

Design

Cross-sectional

Authors

LPL. PollerCross-Cutting CardiologyJTJ M ThomsonWithington Community HospitalKYK. F. YeePhysikalisch-Technische Bundesanstalt

Discussion

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Member takes

Implication

Automation does not reduce inter-laboratory PT error; leaves open whether standardized calibration mitigates technique variables.

Structured PICO

Do automated techniques for the prothrombin time test reduce inter-laboratory error compared to manual techniques?

P
Population
Hospitals participating in prothrombin time proficiency assessment trials organized by the National (U.K.) Reference Laboratory for Anticoagulant Reagents and Control
I
Intervention
Automated procedures for the prothrombin time test
C
Comparator
Recommended manual technique for the prothrombin time test
O
Outcome
Inter-laboratory error and prothrombin time estimationssurrogate

Automated prothrombin time testing does not reduce inter-laboratory error compared to manual techniques, highlighting the need for regular calibration using a standardized system.

Limitations

  • Too much variation in the performance of individual instruments of the same make

Cite This Study

Poller et al. (1978) studied this question.

synapsesocial.com/papers/6a7013fdb27f158178272f25https://doi.org/10.1111/j.1365-2141.1978.tb01059.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of Two Automated Coagulometers and the Manual Tilt-Tube Method for the Determination of Prothrombin Time1989 · 60 citations
  2. 2Automation and prothrombin time: a United Kingdom field study of two widely used coagulometers.1990 · 43 citations
  3. 3Proficiency Testing and Standardization of Prothrombin Time: Effect of Thromboplastin, Instrumentation, and Plasma1984 · 36 citations
  4. 4Imprecision of Prothrombin Time Monitoring of Oral Anticoagulation: A Survey of Hospital Laboratories1992 · 25 citations
  5. 5A Novel Whole Blood Capillary Technic for Measuring the Prothrombin Time1987 · 91 citations