Why the study?
Does the use of automated coagulometers compared to the manual tilt-tube method affect the determination of prothrombin time and INR in normal subjects, patients with liver disease, and patients on oral anticoagulation?
Population
90 subjects
Comparison
Automated coagulometers using 7 ISI-calibrated… vs Manual tilt-tube method
Design
Other
Authors
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Coagulometer INR values may overestimate anticoagulation intensity versus manual methods; leaves open questions on standardization across instruments and reagents.
Does the use of automated coagulometers compared to the manual tilt-tube method affect the determination of prothrombin time and INR in normal subjects, patients with liver disease, and patients on oral anticoagulation?
Automated coagulometers can yield significantly different INR values compared to manual methods, highlighting the need for standardization of both instruments and reagents for monitoring oral anticoagulation.
D’Angelo et al. (1989) studied this question.
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