Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 1, 1990Journal of Clinical PathologyOpen Access

Automation and prothrombin time: a United Kingdom field study of two widely used coagulometers.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Do automated coagulometers (KC4/KC10 and Coag-a-Mate) provide prothrombin time and INR results comparable to the manual method?

Population

20 abnormal blood samples covering a wide spectrum of International Normalised Ratio (INR)

Comparison

Measurement of prothrombin time using KC4/KC10… vs Manual method for prothrombin time measurement

Design

Cross-sectional

Authors

JTJ M ThomsonWithington Community HospitalDTD A TabernerWithington Community HospitalLPL. PollerCross-Cutting Cardiology

Discussion

Loading...

Member takes

Implication

INR discrepancies across coagulometers may affect warfarin dosing; leaves open need for instrument-specific calibration before replacing manual methods.

Structured PICO

Do automated coagulometers (KC4/KC10 and Coag-a-Mate) provide prothrombin time and INR results comparable to the manual method?

P
Population
20 abnormal blood samples covering a wide spectrum of International Normalised Ratio (INR)
I
Intervention
Measurement of prothrombin time using KC4/KC10 and Coag-a-Mate automated coagulometers
C
Comparator
Manual method for prothrombin time measurement
O
Outcome
Agreement of coagulometer prothrombin time and INR results with manual reference valuessurrogate

Significant variation exists between different automated coagulometers and manual methods for INR calculation, which could impact warfarin dosing in clinical practice.

Cite This Study

Thomson et al. (1990) studied this question.

synapsesocial.com/papers/6a7013fbb27f158178272f20https://doi.org/10.1136/jcp.43.8.679
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of Two Automated Coagulometers and the Manual Tilt-Tube Method for the Determination of Prothrombin Time1989 · 60 citations
  2. 2Automated versus Manual Techniques for the Prothrombin Time Test: Results of Proficiency Assessment Studies1978 · 12 citations
  3. 3The correction of coagulometer effects on international normalized ratios: a multicentre evaluation1994 · 47 citations
  4. 4Accuracy, Clinical Correlation, and Patient Acceptance of Two Handheld Prothrombin Time Monitoring Devices in the Ambulatory Setting1999 · 42 citations
  5. 5Comparative Study of a Portable Prothrombin Time Monitor Employing Three Different Systems in Oral Anticoagulant Units2001 · 13 citations