Why the study?
Cardiac side population cells had been studied exclusively in cell culture or after transplantation, limiting understanding of their in vivo function in cardiac regeneration.
Population
Abcg2-driven lineage-tracing mouse model
Comparison
Homeostatic conditions vs cardiac injury
Design
Lineage-tracing animal study
Authors
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SP cells may contribute modestly to cardiomyocyte renewal in vivo; leaves open their therapeutic targeting in humans.
This study provides the first in vivo evidence that cardiac side population cells contribute to endogenous cardiac regeneration by fusing with preexisting cardiomyocytes to trigger cell cycle reentry.
Yellamilli et al. (2020) studied this question.
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