What question did this study set out to answer?

The study aims to define the natural history and predictive value of microalbuminuria in children with type 1 diabetes diagnosed before age 16.

March 1, 1999Diabetes Care

Microalbuminuria prevalence varies with age, sex, and puberty in children with type 1 diabetes followed from diagnosis in a longitudinal study. Oxford Regional Prospective Study Group.

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Population

514 children (279 male) who developed type 1 diabetes before the age of 16 years

Design

Cohort

Follow-up

up to 11 years (287 followed for > 4.5 years)

Authors

CSCarl SchultzInterventional Cardiology TKT. Konopelska‐BahuAddenbrooke's Hospital RDR.N. DaltonRoyal Free London NHS Foundation Trust

Discussion

Member takes

Implication

Supports vigilant postpubertal monitoring in females with higher HbA1c; leaves open whether intensified control alters microalbuminuria risk.

Key Points

The study aims to define the natural history and predictive value of microalbuminuria in children with type 1 diabetes diagnosed before age 16.
Longitudinal study involving 514 children with type 1 diabetes recruited between 1985 and 1996.
Annual assessments of HbA1c and urine samples for albumin excretion were conducted.
Dropout rates were less than 1% per year, with an average follow-up of more than 4.5 years.
Microalbuminuria developed in 12.8% of subjects with 4.8% experiencing persistent microalbuminuria.
Cumulative probability of developing microalbuminuria was 40% after 11 years.
Female subjects had a 200% greater risk, and risk increased by 36% for each 1% increase in HbA1c.

Structured PICO

Population

514 children (279 male) who developed type 1 diabetes before the age of 16 years

Outcome

Development of microalbuminuria (MA)surrogate

In children with type 1 diabetes, prepubertal duration of diabetes and hyperglycemia contribute to the risk of postpubertal microalbuminuria, with higher rates in females and those with worse glycemic control.

Cite This Study

Schultz et al. (1999) studied this question.

synapsesocial.com/papers/6a701dd7febe604dd708e931 https://doi.org/10.2337/diacare.22.3.495

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Implication

Supports vigilant postpubertal monitoring in females with higher HbA1c; leaves open whether intensified control alters microalbuminuria risk.

Microalbuminuria prevalence varies with age, sex, and puberty in children with type 1 diabetes followed from diagnosis in a longitudinal study. Oxford Regional Prospective Study Group.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Microalbuminuria prevalence varies with age, sex, and puberty in children with type 1 diabetes followed from diagnosis in a longitudinal study. Oxford Regional Prospective Study Group.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider