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March 1, 2001Diabetes Care

Blood Pressure Does Not Rise Before the Onset of Microalbuminuria in Children Followed From Diagnosis of Type 1 Diabetes

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Why the study?

Does blood pressure rise before the onset of microalbuminuria in children with type 1 diabetes?

Population

189 children with type 1 diabetes drawn from an incident cohort of 494 children, mean age at diagnosis 9.8…

Design

Case-control

Follow-up

assessed annually from diagnosis

Authors

CSCarl SchultzInterventional CardiologyHNH. A. W. NeilUniversity of UlsterRDR. Neil DaltonNational Health Service

Discussion

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Implication

Absence of pre-microalbuminuria BP rise does not support earlier intervention; leaves open concurrent BMI-related mechanisms in pediatric T1D.

Structured PICO

Does blood pressure rise before the onset of microalbuminuria in children with type 1 diabetes?

P
Population
189 children with type 1 diabetes (63 cases who developed microalbuminuria and 126 matched normoalbuminuric controls) drawn from an incident cohort of 494 children, mean age at diagnosis 9.8 +/- 3.7 years.
C
Comparator
Normoalbuminuric control subjects matched for sex and age at diagnosis
O
Outcome
Systolic and diastolic blood pressure levels before and at the onset of microalbuminuriasurrogate

Blood pressure does not rise before the onset of microalbuminuria in children with type 1 diabetes, but rises concurrently with its onset and is closely related to BMI.

Cite This Study

Schultz et al. (2001) studied this question.

synapsesocial.com/papers/6a88f308b0777cad5fa2a0a8https://doi.org/10.2337/diacare.24.3.555

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A comparison of the random-zero and standard mercury sphygmomanometers.1988 · 48 citations
  2. 2Risk factors for development of microalbuminuria in insulin dependent diabetic patients: a cohort study. Microalbuminuria Collaborative Study Group, United Kingdom.1993 · 137 citations
  3. 3Enhanced Responsiveness of Blood Pressure to Sodium Intake and to Angiotensin II Is Associated With Insulin Resistance in IDDM Patients With Mcroalbuminuria1998 · 44 citations
  4. 4The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus1993 · 24,821 citations
  5. 5Impaired Insulin Action in Puberty1986 · 963 citations