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November 1, 1997Journal of Hypertension

Clinical results of the Verapamil in Hypertension and Atherosclerosis Study

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Why the study?

Does verapamil compared to chlorthalidone improve blood pressure, clinical safety, and carotid wall lesions in hypertensive patients?

Population

1414 hypertensive patients, mean age 53.2 +/- 7 years, baseline blood pressure 168.9 +/- 10.5/102.2 +/- 5.0…

Comparison

Verapamil sustained-release 240 mg once a day… vs Chlorthalidone 25 mg once a day for 2 years.

Design

RCT, assigned randomly, double blind for the first 6 months and open thereafter

Follow-up

2 years

Authors

EREnrico Agabiti RoseiPreventive CardiologyCPC. Dal PalúUniversity of VeronaGLGastone LeonettiUniversity of Siena

Discussion

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Implication

Verapamil matches chlorthalidone for BP control and CV events; confirms equivalence with metabolic advantages in hypertension.

Structured PICO

Does verapamil compared to chlorthalidone improve blood pressure, clinical safety, and carotid wall lesions in hypertensive patients?

P
Population
1414 hypertensive patients (692 men and 722 women), mean age 53.2 +/- 7 years, baseline blood pressure 168.9 +/- 10.5/102.2 +/- 5.0 mmHg.
I
Intervention
Verapamil sustained-release 240 mg once a day for 2 years (with captopril 25-50 mg/day added for non-responders).
C
Comparator
Chlorthalidone 25 mg once a day for 2 years (with captopril 25-50 mg/day added for non-responders).
O
Outcome
Long-term effects on blood pressure, clinical safety, and the progression/regression of carotid wall lesions.surrogate

Verapamil and chlorthalidone provide similar long-term blood pressure reduction and cardiovascular event rates, but verapamil has a more favorable metabolic profile regarding uric acid and potassium.

Cite This Study

Rosei et al. (1997) studied this question.

synapsesocial.com/papers/6a701e486c240de38cdbae8fhttps://doi.org/10.1097/00004872-199715110-00019

Topics

Hypertension management
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