Adrenocorticotrophin-induced hypertension in the rat: haemodynamic, metabolic and morphological characteristics

Q: What is the clinical evidence from this study?

Population: Hypertension (n=44). Intervention: Adrenocorticotrophin (ACTH) vs. Sham injection. Primary outcome: Systolic blood pressure (SBP) (p=<0.02).

Q: What does this research mean for the field?

ACTH administration significantly increases systolic blood pressure and induces metabolic and electrolyte alterations in rats through an adrenal-dependent mechanism. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Judith A. Whitworth; Tim D. Hewitson; Li Ming; Rohan S. Wilson; Bruce A. Scoggins; R. D. Wright; Priscilla Kincaid‐Smith

doi:10.1097/00004872-199001000-00006

January 1, 1990Journal of Hypertension

Adrenocorticotrophin-induced hypertension in the rat: haemodynamic, metabolic and morphological characteristics

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P

Population

44 male Sprague-Dawley rats (including sham and adrenalectomized groups) studied over 12 days to assess the hemodynamic effects of ACTH.

I

Intervention / Comparator

Adrenocorticotrophin (ACTH) vs Sham injection (0.5 mg/kg once daily)

O

Primary Outcome

Systolic blood pressure (SBP), p=<0.02

Main Result

p-value: p=<0.02

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Cite This Study

Whitworth et al. (1990) studied Hypertension (n=44). Adrenocorticotrophin (ACTH) vs. Sham injection was evaluated on Systolic blood pressure (SBP) (p=<0.02).

synapsesocial.com/papers/6a701e4baf0c21e93927fca9 https://doi.org/10.1097/00004872-199001000-00006

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Adrenocorticotrophin-induced hypertension in the rat: haemodynamic, metabolic and morphological characteristics

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Adrenocorticotrophin-induced hypertension in the rat: haemodynamic, metabolic and morphological characteristics

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