Why the study?
Does Doppler echocardiography accurately detect acute cardiac rejection in orthotopic heart transplant patients compared to endomyocardial biopsy?
Population
40 patients who underwent orthotopic heart transplantation, stratified by endomyocardial biopsy results into…
Comparison
Serial Doppler echocardiographic examination… vs Endomyocardial biopsy as the reference standard…
Design
Cohort
Authors
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May flag severe rejection on echo in heart transplant recipients; leaves open Doppler accuracy versus biopsy.
Does Doppler echocardiography accurately detect acute cardiac rejection in orthotopic heart transplant patients compared to endomyocardial biopsy?
Doppler echocardiography can identify severe acute heart transplant rejection with excellent specificity, but it lacks sufficient sensitivity to replace endomyocardial biopsy.
Pellicelli et al. (1996) studied this question.
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