Combined Effects of Caffeine and Alcohol on Hemodynamics and Coronary Artery Blood Flow in Dogs

15 dogs (preclinical model)

Short-term administration of caffeine (5 mg/kg i.v.) followed by ethanol (400 mg/kg i.v.), or the reverse sequence

Controls

Hemodynamics and coronary artery blood flow (including heart rate, mean arterial pressure, left ventricular systolic pressure, left ventricular mechanical work, maximal rate of first derivative of LV pressure, stroke volume, systemic vascular resistance, left ventricular end-diastolic pressure, pulmonary artery mean pressure, right atrial pressure, pulmonary vascular resistance, myocardial oxygen consumption, and coronary flow reserve)surrogate