Why the study?
Does insulin reduce the exaggerated glucagon response to intravenous arginine in patients with diabetes mellitus?
Does insulin reduce the exaggerated glucagon response to intravenous arginine in patients with diabetes mellitus?
Supraphysiologic insulin normalizes the exaggerated glucagon response to arginine in juvenile-onset but not adult-onset diabetes.
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Differential insulin effect on glucagon by diabetes subtype supports subtype-specific pathophysiology; hypothesis-generating and should not change practice.
Raskin et al. (1976) studied this question.
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