Why the study?
Do ouabain and diphenylhydantoin alter transmembrane resting potentials, ionic gradients, and cell pH in rat muscle and liver in vivo?
Population
Rat muscle and liver in vivo
Design
Preclinical
Authors
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These rat tissue effects remain hypothesis-generating; leaves open whether Na/K-ATPase modulation alters human muscle or hepatic electrophysiology.
Do ouabain and diphenylhydantoin alter transmembrane resting potentials, ionic gradients, and cell pH in rat muscle and liver in vivo?
Ouabain and DPH alter transmembrane resting potentials and ionic gradients in rat muscle and liver, supporting a loose coupling between active H+ and Na+-K+ transport.
Williams et al. (1971) studied this question.
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