Population
Quiescent guinea-pig ventricular muscle
Design
Preclinical
Authors
Loading...
May explain Na/K effects on glycoside inotropy via pump affinity changes; hypothesis-generating, should not yet change practice.
The effects of external sodium and potassium on the positive inotropic action of cardiac glycosides can be fully accounted for by marked changes in the apparent binding affinity of the drug to the Na-K pump.
J Daut (1983) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: