Key result
The antagonism between extracellular potassium and dihydro-ouabain on the activation of the Na+-K+ pump current in rat and guinea-pig cardiac cells is non-competitive.
Population
Isolated ventricular cells (myocytes) from rats and guinea-pigs
Comparison
Extracellular potassium ions and dihydro-ouabain vs Varying concentrations of K+o and DHO, and…
Design
Preclinical
Authors
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Non-competitive antagonism in rodent myocytes does not alter digoxin–potassium management; leaves open confirmation in human ventricular cells.
The study demonstrates that the antagonism between extracellular potassium and dihydro-ouabain on the Na+-K+ pump current in rat and guinea-pig ventricular myocytes is non-competitive.
Hermans et al. (1995) studied this question. Dihydro-ouabain (DHO) and extracellular potassium (K+o) was evaluated on Na(+)-K+ pump current (Ip) inhibition and activation. The antagonism between extracellular potassium and dihydro-ouabain on the activation of the Na+-K+ pump current in rat and guinea-pig cardiac cells is non-competitive.
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