Why the study?
Does candesartan improve diastolic dysfunction and alter myocardial collagen turnover in type 2 diabetic patients?
Population
48 type 2 diabetic patients
Comparison
Candesartan for 6 months vs No candesartan (control group)
Design
Cohort
Follow-up
6 months
Authors
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Candesartan was associated with E/A improvement in T2DM; leaves open whether ARBs causally alter collagen turnover or diastolic function.
Does candesartan improve diastolic dysfunction and alter myocardial collagen turnover in type 2 diabetic patients?
Chronic ARB therapy with candesartan improves diastolic dysfunction and attenuates myocardial fibrosis in type 2 diabetic patients by facilitating collagen degradation.
Kawasaki et al. (2007) studied this question.
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