Circulating CA16 strains in China are complex recombinant forms involving multiple human enteroviruses.
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May inform HFMD surveillance; leaves open whether recombinants alter severity or vaccine response.
To determine the relationship of coxsackievirus A16 (CA16) to prototype CA16-G10, we conducted a phylogenetic analysis of circulating CA16 strains in China. Complex recombinant forms of CA16-related viruses involving multiple human enteroviruses, subgroup A (CA4, CA16, and enterovirus 71), are prevalent among patients with hand, foot, and mouth disease.
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Ke Zhao (2011) studied this question.
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