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October 1, 1973Journal of Neurochemistry

Gangliosides of Human Myelin: Sialosylgalactosylceramide (G7) as a Major Component

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Population

Purified human myelin, adult human white matter, and myelin from other mammalian species

Design

Preclinical

Authors

RLRobert W. LedeenRutgers, The State University of New JerseyRYRobert K. YuCarle Foundation HospitalLELawrence F. EngSRI International

Discussion

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Implication

G7 identified as major myelin ganglioside; leaves open its metabolic relationship with cerebroside or sulphatide in humans.

Structured PICO

P
Population
Purified human myelin, adult human white matter, and myelin from other mammalian species
I
Intervention
Isolation of total gangliosides using DEAE-Sephadex column chromatography
O
Outcome
Yield and composition of gangliosides, specifically sialosylgalactosylceramide (G7)

Sialosylgalactosylceramide (G7) is identified as a major ganglioside component of human myelin, suggesting a metabolic relationship with cerebroside or sulphatide.

Cite This Study

Ledeen et al. (1973) studied this question.

synapsesocial.com/papers/6a70359ff44fa9f079ddc81ehttps://doi.org/10.1111/j.1471-4159.1973.tb07527.x
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1FORMATION AND TURNOVER OF MYELIN GANGLIOSIDE*1970 · 66 citations
  2. 2Fatty acid and long chain base composition of adrenal medulla gangliosides1970 · 22 citations
  3. 3Fatty acid and fatty aldehyde composition of the major brain lipids in normal human gray matter, white matter, and myelin1965 · 485 citations