Carbamazepine may modify the clinical presentation of neuroleptic malignant syndrome by masking the typical symptom of fever.
May warrant vigilance for atypical NMS in carbamazepine-treated patients; single case report leaves open whether the drug modifies presentation.
A woman developed rigidity, autonomic instability and altered consciousness after taking an overdose of trifluoperazine and carbamazepine. A diagnosis of NMS was made despite the absence of fever, as carbamazepine might modify the presentation of NMS.
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Dalkin et al. (1990) studied this question.