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April 1, 1982AnesthesiologyOpen Access

Dantrolene in Human Malignant Hyperthermia A Multicenter Study

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Why the study?

Does intravenous dantrolene improve recovery and reduce mortality in patients with anesthetically related malignant hyperthermia?

Population

21 patients treated with dantrolene for anesthetically related malignant hyperthermia across 65…

Design

Cohort

Authors

MKMary Elizabeth KolbUniversitätsklinikum TübingenMHM. L. HorneVanderbilt University Medical CenterRMRobert MartzIndiana University Health

Discussion

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Implication

Supports prompt dantrolene in MH; leaves open causal confirmation without randomized trials.

Structured PICO

Does intravenous dantrolene improve recovery and reduce mortality in patients with anesthetically related malignant hyperthermia?

P
Population
21 patients treated with dantrolene for anesthetically related malignant hyperthermia (MH) across 65 institutions, of which 11 had unequivocal or probable MH and were treated according to study protocol.
I
Intervention
Lyophilized intravenous dantrolene sodium (mean dose 2.5 mg/kg)
O
Outcome
Recovery from malignant hyperthermia and mortality ratehard clinical

Intravenous dantrolene is highly effective in reversing anesthetically related malignant hyperthermia, significantly reducing mortality when administered promptly.

Cite This Study

Kolb et al. (1982) studied this question.

synapsesocial.com/papers/6a703dc2f44fa9f079ddd1fahttps://doi.org/10.1097/00000542-198204000-00005
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