Population
9 volunteers, weight 55-89 kg
Design
Other
Follow-up
up to 60 hours
Authors
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May support infusion regimens for dantrolene plasma stability; leaves open clinical validation in larger cohorts.
A two-compartment pharmacokinetic model for dantrolene suggests that an infusion regimen adjusted to the initial bolus dose can maintain individualized therapeutic concentrations and improve plasma stability compared to intermittent bolus administration.
Podranski et al. (2005) studied this question.
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