Why the study?
Does a specific preoperative oral dantrolene regimen result in protective blood levels at induction of anesthesia in malignant hyperthermia-susceptible patients?
Population
10 malignant hyperthermia-susceptible (MHS) patients
Design
Case_series
Follow-up
48 hours
Authors
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May support oral dantrolene premedication in MH-susceptible patients; hypothesis-generating and requires larger trials before practice change.
Does a specific preoperative oral dantrolene regimen result in protective blood levels at induction of anesthesia in malignant hyperthermia-susceptible patients?
A specific preoperative oral dantrolene regimen provides protective plasma levels for 6-18 hours after induction of anesthesia in malignant hyperthermia-susceptible patients.
Allen et al. (1988) studied this question.
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