Why the study?
Does intravenous dantrolene at the ED95 muscle relaxant dose prevent or treat malignant hyperthermia in MHS swine?
Population
8 malignant hyperthermia-susceptible (MHS) pigs (two groups of 4)
Comparison
Intravenous dantrolene at the ED95 relaxant dose… vs No dantrolene prophylaxis or therapeusis
Design
Preclinical
Authors
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Supports dantrolene efficacy in MHS swine models; leaves open translation to human MH prevention or treatment.
Does intravenous dantrolene at the ED95 muscle relaxant dose prevent or treat malignant hyperthermia in MHS swine?
The ED95 muscle relaxant dose of dantrolene (3.5 mg/kg) is highly effective for both the prevention and treatment of malignant hyperthermia in susceptible swine.
Flewellen et al. (1980) studied this question.
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