Key result
Dantrolene (5 mg/kg) significantly reduced acute muscle lesions in stress-susceptible pigs subjected to experimental restraint stress compared to untreated controls.
Why the study?
Does dantrolene reduce acute skeletal muscle lesions in stress-susceptible pigs exposed to experimental restraint stress?
Does dantrolene reduce acute skeletal muscle lesions in stress-susceptible pigs exposed to experimental restraint stress?
Dantrolene significantly reduces acute skeletal muscle lesions induced by experimental restraint stress in stress-susceptible pigs, supporting the role of increased myoplasmic Ca2+ in these lesions.
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Hypothesis-generating in porcine stress myopathy; leaves open translation to human calcium-modulating therapies.
Bjurström et al. (1995) studied Malignant hyperthermia (n=9). Dantrolene vs. Untreated stress-susceptible pigs was evaluated on Acute muscle lesions. Dantrolene (5 mg/kg) significantly reduced acute muscle lesions in stress-susceptible pigs subjected to experimental restraint stress compared to untreated controls.
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