Population
HeLa cells with modified endoplasmic reticulum membranes expressing different cellular or viral…
Comparison
Superinfection with Poliovirus (PV) vs Cultures expressing soluble proteins
Design
Preclinical
Authors
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This cell-culture result warrants no clinical translation; leaves open whether cis-coupled replication can be targeted for antivirals.
The formation of the poliovirus replication complex requires a coupled process of viral translation, membrane modification, vesicle budding, and viral RNA synthesis in cis.
Egger et al. (2000) studied this question.
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