Population
HeLa cells infected with poliovirus (PV)
Comparison
Guanidine/HCl to induce transcriptionally silent… vs Active replication complexes (no guanidine block)
Design
Preclinical
Authors
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No direct clinical implications from HeLa cell data; leaves open whether trafficking patterns extend to in vivo pathogenesis or other viruses.
The study demonstrates that the transcriptional activity of poliovirus replication complexes determines their intracellular localization and trafficking pathways in HeLa cells.
Egger et al. (2005) studied this question.
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