October 1, 1986The Journal of Cell BiologyOpen Access

Monoclonal antibodies binding to the tail of Dictyostelium discoideum myosin: their effects on antiparallel and parallel assembly and actin-activated ATPase activity.

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Population

Dictyostelium discoideum myosin

Design

Preclinical

Authors

KPKathryn I. PaghDuke Medical Center GGG GerischMax Planck Institute of Biochemistry

Discussion

Member takes

Implication

Antibody tools probe myosin assembly modes; leaves open extension to cardiac myosin research.

Structured PICO

Population

Dictyostelium discoideum myosin

Intervention

Eight monoclonal antibodies binding to specific sites on the tail of Dictyostelium discoideum myosin

Outcome

Effects on polymerization and actin-activated ATPase activitysurrogate

Monoclonal antibodies can be used to dissect parallel from antiparallel assembly of Dictyostelium discoideum myosin and demonstrate that normal actin-activated ATPase activity can occur despite reduced filament size.

Cite This Study

Pagh et al. (1986) studied this question.

synapsesocial.com/papers/6a704fe0febe604dd709181a https://doi.org/10.1083/jcb.103.4.1527

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Monoclonal antibodies binding to the tail of Dictyostelium discoideum myosin: their effects on antiparallel and parallel assembly and actin-activated ATPase activity.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Monoclonal antibodies binding to the tail of Dictyostelium discoideum myosin: their effects on antiparallel and parallel assembly and actin-activated ATPase activity.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider