Experimental study demonstrates enhanced solubility and dissolution of simvastatin via beta-cyclodextrin solid dispersions, suggesting improved oral drug bioavailability.
Simvastatin is a poorly soluble drug exhibiting poor dissolution pattern. Simvastatin-β cyclodextrin dispersions were prepared with a view to study the influence of β-CD on solubility and dissolution of this poorly soluble drug Simvastatin. Solid dispersions of Simvastatin were prepared using different ratios of β-CD as carrier by Physical mixture, solvent evaporation method, Kneading method and Fusion Method. They were evaluated for drug content, moisture content, FTIR spectral studies, solubility, in-vitro dissolution and release kinetics. The solubility profile indicated that there is increase in solubility of Simvastatin when β-CD concentration is increased. The solid dispersion complex of drug (1:5 ratios) was giving better dissolution profile as compared to pure drug and other solid dispersions (1:1 and 1:3). This in turn can improve the bioavailability. FT-IR shows the complexation and compatibility of rug and carrier.
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Punitha et al. (2011) studied this question.
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