February 1, 2002Hypertension

Nitric Oxide Blockade Enhances Renal Responses to Superoxide Dismutase Inhibition in Dogs

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Why the study?

Does NO synthase inhibition enhance the renal vasoconstrictive, antidiuretic, and antinatriuretic effects of superoxide anion in anesthetized dogs?

Structured PICO

Does NO synthase inhibition enhance the renal vasoconstrictive, antidiuretic, and antinatriuretic effects of superoxide anion in anesthetized dogs?

Population

Anesthetized dogs (n=6)

Intervention

Intraarterial infusion of a superoxide dismutase (SOD) inhibitor, diethyldithiocarbamate (DETC; 0.1 and 0.5 mg/kg per min) during NO synthase inhibition with intraarterial administration of nitro-L-arginine (50 microg/kg per min)

Comparator

Intraarterial infusion of DETC alone (before NO synthase inhibition)

Outcome

Renal hemodynamics (cortical, medullary, and total renal blood flow, renal vascular resistance) and excretory function (urine flow, sodium excretion, glomerular filtration rate)surrogate

Superoxide anion exerts renal vasoconstriction and antidiuretic/antinatriuretic effects, which are enhanced during NO synthase blockade, suggesting NO provides a renoprotective effect against superoxide.

Discussion

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Implication

NO may protect renal function against superoxide; extends animal data but leaves open human hypertension relevance.

Cite This Study

Majid et al. (2002) studied this question.

synapsesocial.com/papers/6a70557235aa2c282ce1a37c https://doi.org/10.1161/hy0202.104137

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Nitric Oxide Blockade Enhances Renal Responses to Superoxide Dismutase Inhibition in Dogs

Structured PICO

Discussion

Implication

Cite This Study

Nitric Oxide Blockade Enhances Renal Responses to Superoxide Dismutase Inhibition in Dogs

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider