June 4, 2003HypertensionOpen Access

Increased Renal Medullary H 2 O 2 Leads to Hypertension

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Population

Nonnephrectomized Sprague-Dawley rats with implanted aortic and renal medullary interstitial catheters

Comparison

Renal medullary interstitial infusion of TEMPOL… vs Baseline or alternative infusion combinations

Design

Preclinical

Authors

AMAyako MakinoScripps Research Institute MSM. M. SkeltonMedical College of Wisconsin AZAi-Ping ZouSemmelweis University

Discussion

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Implication

Renal medullary oxidative stress may promote hypertension; hypothesis-generating for human translation and antioxidant targets.

Structured PICO

Population

Nonnephrectomized Sprague-Dawley rats with implanted aortic and renal medullary interstitial catheters

Intervention

Renal medullary interstitial infusion of TEMPOL (10 mg/kg/d) and DETC (7.5 mg/kg/d) with or without catalase (5 mg/kg/d), or direct infusion of H2O2

Comparator

Baseline or alternative infusion combinations

Outcome

Arterial blood pressuresurrogate

Accumulated H2O2 in the renal medulla associated with exaggerated oxidative stress has a hypertensive consequence, and catalase activity is a prerequisite for the antihypertensive action of TEMPOL.

Cite This Study

Makino et al. (2003) studied this question.

synapsesocial.com/papers/6a7693ff5f7f0b63027d1cee https://doi.org/10.1161/01.hyp.0000074903.96928.91

Topics

Hypertension management

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Increased Renal Medullary H 2 O 2 Leads to Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Increased Renal Medullary H 2 O 2 Leads to Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

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