Why the study?
Does increased oxidative stress within the renal medulla via DETC infusion lower medullary blood flow and lead to hypertension in uninephrectomized Sprague-Dawley rats?
Does increased oxidative stress within the renal medulla via DETC infusion lower medullary blood flow and lead to hypertension in uninephrectomized Sprague-Dawley rats?
Chronic increased oxidative stress within the renal medulla selectively reduces medullary blood flow and produces hypertension in a rat model.
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Medullary oxidative stress may induce hypertension in this rat model; leaves open relevance to human disease.
Makino et al. (2002) studied this question.
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