What question did this study set out to answer?

To determine the relationship between left ventricular hypertrophy and cardiac autonomic function assessed by heart rate variability.

February 1, 1995HeartOpen Access

Heart rate variability in left ventricular hypertrophy.

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Why the study?

Does left ventricular hypertrophy reduce heart rate variability compared to controls?

Population

190 individuals, comprising 154 patients with left ventricular hypertrophy and 36 controls, evaluated at a…

Comparison

Left ventricular hypertrophy vs Controls without left ventricular hypertrophy

Design

Case-control

Authors

MMMahendra K. MandawatAugusta University DWDavid WallbridgeRoyal Shrewsbury Hospital SPStuart D. PringleQueen's University Belfast

Discussion

Member takes

Implication

LVH may impair autonomic function; hypothesis-generating for reduced HRV as mediator of sudden death risk.

Key Points

To determine the relationship between left ventricular hypertrophy and cardiac autonomic function assessed by heart rate variability.
Assessed 154 patients with left ventricular hypertrophy (94 with hypertension and 60 with aortic valve disease) alongside 36 healthy controls at a tertiary referral centre.
Measured heart rate variability from 24-hour Holter recordings using non-spectral methods.
Determined left ventricular mass index and fractional shortening via echocardiography.
Patients with left ventricular hypertrophy demonstrated a significantly higher left ventricular mass index (P < 0.001) and reduced heart rate variability (P < 0.001) compared with controls.
Heart rate variability exhibited a significant continuous inverse correlation with left ventricular mass index (r = -0.478, P < 0.001).
Multivariate analysis confirmed that left ventricular mass index was the most significant determinant of heart rate variability, independent of age, coronary artery disease, or beta-blocker therapy.

Structured PICO

Does left ventricular hypertrophy reduce heart rate variability compared to controls?

Population

190 individuals, comprising 154 patients with left ventricular hypertrophy (94 with hypertension and 60 with aortic valve disease) and 36 controls, evaluated at a tertiary referral centre.

Intervention

Left ventricular hypertrophy (secondary to hypertension or aortic valve disease)

Comparator

Controls without left ventricular hypertrophy

Outcome

Heart rate variability measured on 24 h Holter recordings by non-spectral methodssurrogate

Left ventricular hypertrophy is associated with impaired cardiac autonomic function as evidenced by reduced heart rate variability, which may contribute to the risk of sudden death.

Cite This Study

Mandawat et al. (1995) studied this question.

synapsesocial.com/papers/6a7055c835aa2c282ce1a46d https://doi.org/10.1136/hrt.73.2.139

Topics

Hypertension management

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Heart rate variability in left ventricular hypertrophy.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Heart rate variability in left ventricular hypertrophy.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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