Why the study?
Does nicardipine, captopril, or their combination reduce blood pressure and improve renal function in hypertensive type II diabetic patients with nephropathy?
Population
12 hypertensive type II diabetic outpatients with nephropathy (persistent proteinuria >500 mg/24 h)
Comparison
Nicardipine 20 mg t.i.d., captopril 50 mg… vs Matched placebo
Design
RCT
Follow-up
4 weeks
Authors
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Supports nicardipine or captopril, alone or combined, for BP and albuminuria control in diabetic nephropathy; confirms additive hemodynamic benefits with stable GFR.
Does nicardipine, captopril, or their combination reduce blood pressure and improve renal function in hypertensive type II diabetic patients with nephropathy?
Nicardipine and captopril, alone or in combination, effectively reduce blood pressure and urinary albumin excretion in hypertensive type II diabetic patients with nephropathy.
Stornello et al. (1989) studied this question.
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