Why the study?
Do captopril or nifedipine affect urinary albumin excretion in normotensive patients with insulin-dependent diabetes and incipient nephropathy?
Population
Normotensive patients with insulin-dependent diabetes and incipient nephropathy
Comparison
Captopril or nifedipine for 6 weeks vs Placebo
Follow-up
6 weeks
Authors
Loading...
May favor captopril over nifedipine for albuminuria despite equivalent BP effects; leaves open class-specific intrarenal mechanisms for confirmation.
Do captopril or nifedipine affect urinary albumin excretion in normotensive patients with insulin-dependent diabetes and incipient nephropathy?
Captopril and nifedipine have opposite effects on urinary albumin excretion in normotensive patients with diabetic nephropathy despite similar blood pressure reductions, suggesting different intrarenal mechanisms.
Mimran et al. (1988) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: