February 15, 1992The Journal of Cell BiologyOpen Access

Perturbations of Drosophila alpha-actinin cause muscle paralysis, weakness, and atrophy but do not confer obvious nonmuscle phenotypes.

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Population

Drosophila fliA mutants (fliA1, fliA3, fliA4)

Design

Preclinical

Authors

ERE M RoulierJohns Hopkins University CFChristine FyrbergJohns Hopkins University EFEric FyrbergUniversity of Massachusetts Chan Medical School

Discussion

Member takes

Implication

Drosophila fliA data warrant caution against clinical extrapolation; leaves open alpha-actinin's stabilizing role and redundant functions for mammalian validation.

Structured PICO

Population

Drosophila fliA mutants (fliA1, fliA3, fliA4)

Intervention

Mutations in the fliA gene affecting alpha-actinin accumulation

Outcome

Muscle paralysis, weakness, atrophy, and myofibril structuresurrogate

In Drosophila, alpha-actinin appears to stabilize and anchor thin filament arrays rather than orchestrating their assembly, with redundant functions in both muscle and nonmuscle cells.

Cite This Study

Roulier et al. (1992) studied this question.

synapsesocial.com/papers/6a7058ca75498292b709c5cb https://doi.org/10.1083/jcb.116.4.911

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Implication

Drosophila fliA data warrant caution against clinical extrapolation; leaves open alpha-actinin's stabilizing role and redundant functions for mammalian validation.

Perturbations of Drosophila alpha-actinin cause muscle paralysis, weakness, and atrophy but do not confer obvious nonmuscle phenotypes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Perturbations of Drosophila alpha-actinin cause muscle paralysis, weakness, and atrophy but do not confer obvious nonmuscle phenotypes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider