Molecular genetics of Drosophila alpha-actinin: mutant alleles disrupt Z disc integrity and muscle insertions.

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Population

Drosophila melanogaster with mutant alleles of the alpha-actinin gene

Design

Preclinical

Authors

Discussion

Alpha-actinin is essential for Drosophila muscle integrity; leaves open its relevance to human cardiac Z-disc disorders.

Population

Drosophila melanogaster with mutant alleles of the alpha-actinin gene

Intervention

Mutations in the alpha-actinin gene (null alleles l(1)2Cb1, l(1)2Cb2, l(1)2Cb4, l(1)2Cb5 and point mutations fliA)

Outcome

Phenotypic effects on development (embryogenesis, larval survival) and muscle ultrastructure (Z disc and myofibrillar attachments)

Drosophila alpha-actinin is essential for larval survival and the structural integrity of Z discs and myofibrillar attachments in muscle cells.

Fyrberg et al. (1990) studied this question.

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