Population
Six strongly dominant negative mutant actins expressed and purified in Dictyostelium
Comparison
Biochemical characterization of mutant actins vs Wild-type actin
Design
Preclinical
Authors
Loading...
Mutant actin classes in Drosophila extend mechanistic hypotheses; leaves open relevance to human cardiomyopathy until mammalian validation.
Dominant negative mutant actins from Drosophila can be classified into three distinct biochemical classes that disrupt wild-type actin function through different mechanisms.
Noguchi et al. (2009) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: