Key result
Abdominal aortic aneurysm was associated with significantly higher serum thrombomodulin concentrations compared to healthy volunteers (3.93 vs 2.37 ng/mL; P<0.001).
Why the study?
Does serum thrombomodulin concentration differ between patients with abdominal aortic aneurysm and healthy volunteers, and does it correlate with endothelial injuring factors?
Case-Control (n=71)
Does serum thrombomodulin concentration differ between patients with abdominal aortic aneurysm and healthy volunteers, and does it correlate with endothelial injuring factors?
Absolute Event Rate: 3.93% vs 2.37%
p-value: p=<0.001
Elevated serum thrombomodulin in AAA patients suggests that endothelial damage occurs in AAA pathogenesis and is associated with lipid abnormalities, inflammation, and oxidative stress.
Elevated thrombomodulin should not yet change AAA practice; leaves open its value as biomarker or progression marker.
Background. The aim of the present study was to evaluate the concentration of serum thrombomodulin (sTM) in the AAA patients and to examine its correlation with various factors which may potentially participate in the endothelial injury. Materials and Methods. Forty-one patients with AAA were involved and divided into subgroups based on different criteria. Concentration of sTM was measured using enzyme-linked-immunosorbent assay (ELISA). The results were compared with those obtained in 30 healthy age- and sex-matched volunteers. Results. The higher concentration of sTM was observed in AAA patients compared with those in controls volunteers [2.37 (1.97–2.82) ng/mL versus 3.93 (2.43–9.20) ng/mL, P < 0.001]. An elevated sTM associated significantly with increased triglycerides (TAG) [ P = 0.022], cholesterol [ P = 0.029], hsCRP [ P = 0.031], and advanced glycation end products (AGEs) [ P = 0.033]. Conclusions. The elevation of serum sTM level suggests that endothelial damage occurs in AAA pathogenesis. The correlations observed indicate that lipids abnormalities, inflammation, and oxidative stress may be involved in this destructive process.
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Budzyń et al. (2017) conducted a case-control in Abdominal Aortic Aneurysm (n=71). Abdominal aortic aneurysm vs. Healthy volunteers was evaluated on Concentration of serum thrombomodulin (sTM) (p=<0.001). Abdominal aortic aneurysm was associated with significantly higher serum thrombomodulin concentrations compared to healthy volunteers (3.93 vs 2.37 ng/mL; P<0.001).
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