October 1, 1983Biochemistry

5'-Conformation of capped alfalfa mosaic virus ribonucleic acid may reflect its independence of the cap structure or of cap-binding protein for efficient translation

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Structured PICO

Population

Alfalfa mosaic virus RNA 4 (AMV-4 RNA)

Intervention

Partial enzymatic digestion with single strand specific and double strand specific nucleases, and in vitro translation with increasing potassium concentration

Comparator

Computer-generated models of AMV-4 secondary structure

Outcome

5'-terminus secondary structure and translatabilitysurrogate

The predominantly single-stranded nature of the 5'-terminus of AMV-4 RNA may explain its efficient translation independent of the cap structure or cap-binding proteins.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May guide viral RNA or synthetic mRNA design; leaves open validation in mammalian systems.

Cite This Study

Gehrke et al. (1983) studied this question.

synapsesocial.com/papers/6a70608de71d69abee08904a https://doi.org/10.1021/bi00291a015

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5'-Conformation of capped alfalfa mosaic virus ribonucleic acid may reflect its independence of the cap structure or of cap-binding protein for efficient translation

Structured PICO

Discussion

Implication

Cite This Study

5'-Conformation of capped alfalfa mosaic virus ribonucleic acid may reflect its independence of the cap structure or of cap-binding protein for efficient translation

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider