Key result
Frequent premature ventricular complexes were associated with significantly prolonged left, right, and interatrial electromechanical delays compared to healthy controls (p≤0.001).
Why the study?
Premature ventricular complexes are common, and prolongation of atrial conduction time indicates electromechanical delay, prompting comparison of atrial conduction parameters between patients with frequent PVC and healthy controls.
Do patients with frequent premature ventricular complexes have prolonged atrial conduction times compared to healthy controls?
Case-Control (n=108)
Do patients with frequent premature ventricular complexes have prolonged atrial conduction times compared to healthy controls?
p-value: p=<0.001
Frequent PVCs are associated with prolonged atrial electromechanical delay, which is more pronounced with wider PVC QRS duration, right ventricular origin, and shorter coupling intervals.
Frequent PVCs may link to atrial EMD; leaves open whether this predicts AF risk in prospective studies.
Background Premature ventricular complex (PVC) is a frequent finding in the general population. The atrial conduction time (ACT) is the period between the electrocardiographic P wave and the atrial mechanical contraction, and its prolongation indicates an atrial electromechanical delay (EMD). In our study, we compared atrial conduction parameters by echocardiographic methods between patients with frequent PVC and healthy control subjects. Methods The study included 54 patients with PVC and 54 healthy volunteers. Atrial conduction parameters were measured with echocardiographic examination. The time difference between the p wave and the Am wave was measured in the septal, lateral, and tricuspid annulus regions. The interatrial EMD, left atrial intra‐atrial delay, and the right atrial intra‐atrial delay were calculated from these measurements. The groups were compared for demographic and electrocardiographic features and echocardiographic parameters. Results Left intra‐atrial EMD, right intra‐atrial EMD, and interatrial EMD were significantly longer in the patient group ( p = .001, p < .001, p < .001, respectively). PA lateral, PA septal, and PA tricuspid durations were significantly prolonged in the patient group (all p < .001). All ACT parameters were significantly prolonged in patients with PVC QRS duration of 150 ms and above (all p < .001). All ACT parameters were prolonged in PVCs of right ventricular origin than those of left ventricular origin (all p < .001). ACT parameters were prolonged in patients with a coupling interval time below 485 ms (all p < .001). Conclusions Atrial conduction times are prolonged in patients with frequent PVC.
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Kahraman et al. (2023) conducted a case-control in Frequent premature ventricular complex (n=108). Frequent premature ventricular complex vs. Healthy volunteers was evaluated on Atrial conduction parameters including interatrial, left intra-atrial, and right intra-atrial electromechanical delays (p=<0.001). Frequent premature ventricular complexes were associated with significantly prolonged left, right, and interatrial electromechanical delays compared to healthy controls (p≤0.001).
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