Key result
Theiler's virus persistence in the central nervous system of mice is multigenic, with H2 class I genes having a major effect on susceptibility and viral proteins L and L* interfering with host defenses.
This review highlights the viral and host genetic factors contributing to the persistent infection and demyelinating disease caused by Theiler's virus in mice.
No takes yet. Share an insight, caveat, or question.
Does not support changes in clinical management of demyelinating diseases; extends mouse model insights into multigenic viral persistence for further research.
Brahic et al. (2005) conducted a review in Theiler's virus infection / multiple sclerosis model. Theiler's virus infection was evaluated. Theiler's virus persistence in the central nervous system of mice is multigenic, with H2 class I genes having a major effect on susceptibility and viral proteins L and L* interfering with host defenses.