Population
Mice models infected with Theiler's virus
Comparison
Genetic modifications vs Different genetic backgrounds (129/Sv vs C57BL/6)
Design
Preclinical
Authors
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Strain-specific interferon effects in Theiler's models do not inform multiple sclerosis care; leaves open analogous genetic loci modulating viral persistence in humans.
Clinical disease in Theiler's virus infection depends on genetic background, specifically high viral load and the Tmevd5 locus on chromosome 11, which may have implications for identifying viruses implicated in multiple sclerosis.
Aubagnac et al. (1999) studied this question.
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