July 5, 1994Proceedings of the National Academy of SciencesOpen Access

Three distinct human thymopoietins are derived from alternatively spliced mRNAs.

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Population

Human tissues (adult thymus and fetal liver)

Design

Preclinical

Authors

CHCrafford A. HarrisJohnson & Johnson (United States)PAPaula J. AndryukMerck & Co., Inc., Rahway, NJ, USA (United States)SCScott W. ClineMemorial Sloan Kettering Cancer Center

Discussion

Member takes

Implication

Premature for clinical use; leaves open isoform-specific roles in thymic immunity and cardiovascular disease.

Structured PICO

Population

Human tissues (adult thymus and fetal liver)

Intervention

Isolation of cDNA clones for alternatively spliced mRNAs encoding human thymopoietins

Outcome

Identification and characterization of three distinct human thymopoietins (TP alpha, TP beta, TP gamma)

The study identifies three distinct human thymopoietins derived from alternatively spliced mRNAs, suggesting unique functions and subcellular localizations.

Cite This Study

Harris et al. (1994) studied this question.

synapsesocial.com/papers/6a707da02163a0a01bc4b3fd https://doi.org/10.1073/pnas.91.14.6283

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Three distinct human thymopoietins are derived from alternatively spliced mRNAs.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Three distinct human thymopoietins are derived from alternatively spliced mRNAs.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider