Mechanism of myocardial contractile depression by clinical concentrations of ethanol. A study in ferret papillary muscles.
Why the study?
Does ethanol depress myocardial contractility via direct effects on electromechanical coupling in isolated ferret papillary muscles?
Population
Isolated ferret right ventricular papillary muscle
Comparison
Ethanol at clinical concentrations and higher… vs Baseline/ethanol-free perfusate
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Ethanol may impair contractility via myofilament effects in isolated muscle; leaves open translation to human myocardium.
Structured PICO
Does ethanol depress myocardial contractility via direct effects on electromechanical coupling in isolated ferret papillary muscles?
P
Population
Isolated ferret right ventricular papillary muscle
I
Intervention
Ethanol at clinical concentrations (0.15 vol %) and higher concentrations
C
Comparator
Baseline/ethanol-free perfusate
O
Outcome
Force of contraction, transmembrane action potential, and cytosolic calcium transientsurrogate
Ethanol at clinical concentrations acutely depresses myocardial contractility by directly inhibiting the calcium-myofilament interaction.
Cite This Study
Guarnieri et al. (1990) studied this question.