Why the study?
Does ethanol acutely suppress excitation-contraction coupling in adult rat cardiac myocytes?
Population
Adult rat cardiac myocytes
Comparison
Ethanol (0.1-5.0% vol/vol) vs Absence of ethanol (baseline)
Design
Preclinical
Follow-up
Acute
Authors
Loading...
Acute ethanol may impair rat myocyte contractility via myofilament Ca2+ desensitization; leaves open relevance to human alcohol cardiomyopathy.
Does ethanol acutely suppress excitation-contraction coupling in adult rat cardiac myocytes?
Ethanol acutely and reversibly depresses cardiac contractility in rat myocytes, likely due to decreased myofilament Ca2+ sensitivity at clinically relevant concentrations.
Danziger et al. (1991) studied this question.