Why the study?
Does diastolic pressure determine autonomic responses to pressure perturbation in normal human subjects?
Population
10 normal human subjects, age 25 +/- 2 (SE) yr
Comparison
Intravenous vasodilator infusion while central… vs Baseline (pre-infusion)
Design
Other
Follow-up
3-min periods
Authors
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Diastolic pressure may primarily drive baroreflex autonomic responses in healthy humans; leaves open clinical translation and therapeutic targeting.
Does diastolic pressure determine autonomic responses to pressure perturbation in normal human subjects?
Diastolic pressure appears to be the primary mechanical determinant of arterial baroreceptor activity regulating sympathetic and heart rate responses in humans.
Sanders et al. (1989) studied this question.
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