Why the study?
Does intra-arterial yohimbine alter forearm blood flow and vascular resistance differently in patients with congestive heart failure compared to normal subjects?
Population
11 patients with congestive heart failure and 15 normal subjects
Comparison
Intra-arterial infusions of subsystemic doses of… vs Normal subjects receiving the same intervention
Design
Other
Authors
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Preserved α2-mediated vascular responses in HF; leaves open whether receptor modulation offers therapeutic benefit in chronic sympathetic activation.
Does intra-arterial yohimbine alter forearm blood flow and vascular resistance differently in patients with congestive heart failure compared to normal subjects?
Alpha 2-receptor-mediated vasoconstriction and inhibition of norepinephrine release remain functional in patients with heart failure despite chronic elevations in plasma norepinephrine.
Kubo et al. (1989) studied this question.
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