Why the study?
Does endothelin receptor antagonism affect coronary resistance and ET-1 release in isolated rat hearts?
Population
Isolated rat hearts (normoxic and reperfused)
Comparison
Infusion of endothelin receptor antagonists PD… vs null
Design
Preclinical
Authors
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ET_B blockade may raise coronary resistance via ET-1 displacement in rat hearts; leaves open relevance of selective antagonism to human coronary tone.
Does endothelin receptor antagonism affect coronary resistance and ET-1 release in isolated rat hearts?
ET(B) receptors play a crucial role in binding and sequestering ET-1, and their blockade displaces ET-1 which then accesses ET(A) receptors to cause coronary constriction.
Brünner et al. (1996) studied this question.
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