Why the study?
Is the functional responsiveness of the cardiac ET-receptor system altered in patients with end-stage chronic heart failure compared to nonfailing hearts?
Population
Slices from right atria and left ventricles from 6 potential heart transplant donors and 15 patients with…
Comparison
In vitro stimulation with endothelin. vs Nonfailing hearts (NFH) vs. end-stage CHF hearts.
Design
Preclinical
Authors
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Preserved ET(A) responsiveness in CHF animal hearts; leaves open whether ET antagonists confer benefit in human end-stage disease.
Is the functional responsiveness of the cardiac ET-receptor system altered in patients with end-stage chronic heart failure compared to nonfailing hearts?
Despite elevated plasma ET-1 levels in chronic heart failure, the functional responsiveness and density of the cardiac ET(A)-receptor system remain unaltered in end-stage disease.
Pönicke et al. (1998) studied this question.
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